Journal
HELVETICA CHIMICA ACTA
Volume 87, Issue 9, Pages 2368-2377Publisher
WILEY-BLACKWELL
DOI: 10.1002/hlca.200490214
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The circular dichroism (CD) spectra of the powerful antimalarian active principle artemisinin (ART; 1) from Artemisia annua, and of epiartemisinin (EPI, 2), its C(7) epimer, were studied in solution in the presence and absence of beta-cyclodextrin (beta-cd). A significant inversion of sign in the region of the second electronic transition was detected. The rotational strengths were successfully calculated within the time-dependent density functional theory (DFT), which enabled us to establish a correlation between the molecular recognition and the biological acitivities of the two isomers.
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