Journal
NEUROTOXICOLOGY
Volume 25, Issue 1-2, Pages 303-315Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0161-813X(03)00117-7
Keywords
semicarbazide-sensitive amine oxidase (SSAO); aldehyde; amiloride-binding protein; diabetes; GLUT-4; hydrogen peroxide; monoamine oxidase; vascular adhesion; VAP-1; xenobiotic
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The semicarbazide-sensitive amine oxidases (SSAO) (EC 1.4.3.6) were believed to be detoxifying enzymes, primarily involved in the oxidative deamination of endogenous amines, such as methylamine and aminoacetone, together with some xenobiotic amines. However, it appears that the reaction products may have important signalling functions in the regulation of cell development and glucose homeostasis. Furthermore, enzyme, from some sources, behaves as a cellular adhesion protein under inflammatory and it may also be involved in lipid transport. This review considers what is known about the activities and potential functions of this hardworking protein. (C) 2003 Elsevier Inc. All rights reserved.
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