Journal
JOURNAL OF NEUROVIROLOGY
Volume 10, Issue 4, Pages 216-222Publisher
SPRINGER
DOI: 10.1080/13550280490463569
Keywords
cranial nerve ganglion; herpes simplex virus; quantitative PCR; viral load
Categories
Ask authors/readers for more resources
A susceptible individual exposed to herpes simplex virus (HSV) will develop latent infection in multiple cranial nerve ganglia. There are a few quantitative studies of the viral load within the trigeminal ganglion, but none that investigate other cranial nerve ganglia. In this study, human trigeminal, geniculate, vestibular ( Scarpa's) and cochlear ( spiral) ganglia were obtained from willed body donors. Real time quantitative polymerase chain reaction (PCR) analysis of the HSV DNA polymerase gene was performed on ipsilateral ganglion sets from the same individual. Viral load, expressed as HSV genomes per 10(5) cells, was significantly greater in the vestibular ganglion (mean +/- SD, 176705 +/- 2555916) than in the geniculate ( 9948 +/- 22066), cochlear ( 3527 +/- 9360), or trigeminal ( 2017 +/- 5578) ganglia. There was not a significant correlation among ganglia from the same individual. The results support the hypothesis that neuronal subpopulations have variable susceptibility to HSV infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available