Journal
DEVELOPMENTAL CELL
Volume 6, Issue 1, Pages 7-28Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(03)00399-X
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Site-specific recombinase systems (Cre-IoxP, Flp-FRT, and phiC31-att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.
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