Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice

Site-specific recombinase systems (Cre-IoxP, Flp-FRT, and phiC31-att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.