Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 27, Issue 1, Pages 106-110Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02980055
Keywords
Acanthopanax senticosus; Araliaceae; s-transaminases CCl4-intoxication; antioxidant enzymes; eleutheroside B; eleutheroside E; DPPH
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The antioxidant activities of Acanthopanax senticosus stems were evaluated in CCl4-intoxicated rats. The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively. The n-butanol fraction whereas showed a significant inhibition of serum GPT activity (65.79% inhibition) elevated with hepatic damage induced by CCl4-intoxication. Eleutheroside B, a lignan component, isolated from the n-butanol fraction was found to cause a moderate free radical scavenging effect on DPPH, its scavenging potency as indicated in IC50 value, being 58.5 muM These results suggested that the stems of A. senticosus possess not only antioxidant but also hepatoprotective activities.
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