Human papillomavirus and extragenital in situ carcinoma

Background: The relation between human papillomavirus (HPV) and extragenital Bowen's disease ( BD) is controversial. Methods: This study used in situ hybridisation to evaluate the rate of HPV in extragenital cutaneous BD and investigated possible relations with immune status and exposure of skin to light. Results: HPV DNA was detected in 58% of 69 samples from 50 patients. The percentage of HPV detection was not significantly higher in exposed (55%) than unexposed areas (65%), and no difference in HPV rate was found between immunosuppressed and immunocompetent patients. Conclusion: Thus, this study confirms the high rate of HPV detection in extragenital cutaneous BD and suggests that there is no apparent relation concerning exposed areas and immune status. Copyright (C) 2004 S. Karger AG, Basel.