Journal
EMBO REPORTS
Volume 5, Issue 1, Pages 35-40Publisher
WILEY
DOI: 10.1038/sj.embor.7400051
Keywords
actin; myosin; cGMP; Ptdlns(3,4,5)P-3; modules
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Chemotaxis is the result of a refined interplay among various intracellular molecules that process spatial and temporal information. Here we present a modular scheme of the complex interactions between the front and the back of cells that allows them to navigate. First, at the front of the cell, activated Rho-type GTPases induce actin polymerization and pseudopod formation. Second, phosphatidylinositol-3,4,5-trisphosphate (Ptdins(3,4,5)P-3) is produced in a patch at the leading edge, where it binds pleckstrinhomology-domain-containing proteins, which enhance actin polymerization and translocation of the pseudopod. Third, in Dictyostelium amoebae, a cyclic-GMP-signalling cascade has been identified that regulates myosin filament formation in the posterior of the cell, thereby inhibiting the formation of lateral pseudopodia that could misdirect the cell.
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