Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 98, Issue 1, Pages 24-32Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2003.09.009
Keywords
imidazole; histidine; dipeptide; potentiometry; copper(II)
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Copper(II) complexes of dipeptides of histidine containing additional chelating bis(imidazol-2-yl) agent at the C-termini (PheHis-BIMA [N-phenylalanyl-histidyl-bis(imidazol-2-yl)methylamine] and HisPhe-BIMA [N-histidyl-phenylalanyl-bis(imidazol-2-yl)methylamine]) were studied by potentiometric, UV-Visible and Electron Paramagnetic Resonance (EPR) techniques. The imidazole nitrogen donor atoms of the bis(imidazol-2-yl)methyl group are described as the primary metal binding sites forming stable mono- and bis(ligand) complexes at acidic pH. The formation of a ligand-bridged dinuclear complex [Cu2L2](4+) is detected in equimolar solutions of copper(II) and HisPhe-BIMA. The coordination isomers of the dinuclear complex are described via the metal binding of the bis(imidazol-2-yl)methyl, amino-carbonyl and amino-imidazole(His) functions. In the case of the copper(II)-PheHis-BIMA system the [NH2, N-(amide), N(Im)] tridentate coordination of the ligand is favoured and results in the formation of di- and trinuclear complexes [Cu2H-1L](3+) and [Cu3H-2L2](4+) in equimolar solutions. The presence of these coordination modes shifts the formation of tripeptide-like ([NH2, N-, N-, N(Im)]-coordinated) [CuH-2L] complexes into alkaline pH range as compared to other dipeptide derivatives of bis(imidazol-2-yl) ligands. Although there are different types of imidazoles in these ligands, the deprotonation and coordination of the pyrrole-type N(I)H groups does not occur below pH 10. (C) 2003 Elsevier Inc. All rights reserved.
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