Journal
ARKIVOC
Volume -, Issue -, Pages 101-109Publisher
ARKAT USA INC
DOI: 10.3998/ark.5550190.0005.109
Keywords
fluorous mixture synthesis; fluorous HPLC; pyridovericin; murisoline; mappicine
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R43GM062717, R44GM062717] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R43 GM062717-01, R44 GM062717-02] Funding Source: Medline
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Fluorous mixture synthesis (FMS) is a newly developed highly-efficient solution-phase technology. A set of substrates attached to homologous fluorous tags is mixed and taken through a sequence of organic reactions. The final mixtures are demixed by fluorous HPLC and detagged to give individually pure final products. Applications of FMS for the preparation of 2 enantiomers of pyridovericin, 16 diastereomers of murisolin, and a 560-member mappicine library are highlighted in this article.
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