Journal
CURRENT MEDICINAL CHEMISTRY
Volume 12, Issue 7, Pages 795-805Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867053507324
Keywords
animals; antibodies; monoclonal; antigens; neoplasm; fluorescent dyes; green fluorescent protein; imaging; nanotechnology; quantum dots
Funding
- NATIONAL CANCER INSTITUTE [R33CA097541] Funding Source: NIH RePORTER
- NCI NIH HHS [CA97541] Funding Source: Medline
- NIEHS NIH HHS [ES00364] Funding Source: Medline
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We review recent progress in tumor imaging in vivo using fluorescent tags, highlight the problems of fluorescence imaging in small animals, discuss recent advances in near-infrared fluorochromes and quantum dots, and point to some future possibilities. GFP-based fluorescence imaging is briefly discussed. The authors believe that improvements in near-infrared fluorochromes are required to enable practical imaging in tissues at centimeter depths.
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