Journal
GENOME BIOLOGY
Volume 6, Issue 11, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/gb-2005-6-11-r97
Keywords
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Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [F32HG002989] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM072518] Funding Source: NIH RePORTER
- NHGRI NIH HHS [F32HG002989, F32 HG002989] Funding Source: Medline
- NIGMS NIH HHS [R01GM072518, R01 GM072518] Funding Source: Medline
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ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide sites of protein-DNA interaction.
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