Journal
LUPUS
Volume 14, Issue 9, Pages 697-701Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1191/0961203305lu2203oa
Keywords
anti-beta 2GPI; antiphosphplipid syndrome; autoimmunity; Libman-Sacks endocarditis; M-protein; rheumatic fever
Categories
Ask authors/readers for more resources
The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of the disease; 3) cross reacting antibodies between the pathogen and self molecules; 4) endothelial cell activation in the 'crime-area' i.e., the valves; 5) some of the patients with RF have circulating antiphospholipid antibodies, while APS may be associated with streptococcal infection; and 6) recently, a cross-reactivity between antibodies directed to the streptococcal M-protein and its synthetic derivative in rheumatic fever (RF) and antibodies derived from APS patients targeting the beta-2-glycoprotein-I (beta 2GPI) and a beta 2GPI related synthetic peptide. In the current paper, we summarize the possible links between the heart involvement in RF and APS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available