Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 6, Issue 1, Pages 79-86Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1552
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How the genetic code is translated into proteins was a key focus of biological research before the 1980s, but how these proteins are degraded remained a neglected area. With the discovery of the lysosome, it was suggested that cellular proteins are degraded in this organelle. However, several independent lines of experimental evidence strongly indicated that non-lysosomal pathways have an important role in intracellular proteolysis, although their identity and mechanisms of action remained obscure. The discovery of the ubiquitin - proteasome system resolved this enigma.
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