Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 166, Issue -, Pages 286-296Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2015.03.030
Keywords
Cyclocarya paliurus; Antihyperlipidemic; ApoB48; TNF-alpha; MAPK; Antioxidant
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Funding
- National Natural Science Foundation of China [31270673]
- Ninth Batch of Six Talent Peaks Project of Jiangsu Province [2012-YY-008]
- Fundamental Research Funds for the Central Universities [ZJ14103]
- National Found for Fostering Talents of Basic Science [J1030830]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Ethnopharmacological relevance: Cyclocarya paliurus (CP) Batal., the sole species in its genus, is a native plant to China. As a traditional Chinese folk medicine, the tree leaves have been widely used for the treatment of metabolic disorders, including hyperlipidemia, obesity, diabetes and hypertension. Aim of the study: The study aimed to evaluate the antihyperlipidemic effect of CP ethanol extract, as well as its inhibitory activity on apolipoproteinB48 (apoB48), in normal and hyperlipidemic mice. Materials and methods: The antihyperlipidemic effect of CP was evaluated in hyperlipidemic mice induced by high-fat diet for 4 weeks. CP ethanol extract (0.37, 0.75 and 1.5 g/kg/day) was orally administrated once daily. Lipids and antioxidant profiles, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), together with the indices of hepatic and renal functions were examined. RT-qPCR and western blotting were used to analysis the expression levels of tumor necrosis factor (TNF-alpha), total- and triglyceride-rich apoB48 (TRL-apoB48), as well as the phosphorylation of the mitogen-activatein kinase (MAPK). Results: CP as well as simvastatin remarkably lowered the levels of TC, TG, LDL-C and MDA, and at the same time, elevated the HDL-C, SOD and GSH-Px in high-fat diet mice. It also decreased the serum concentration of total- and TRL-apol348 in the fasting state. CP inhibited TNF-alpha expression and phosphorylation level of MAPK. Furthermore, the HE staining of liver and kidney, together with hepatic and renal function analysis showed hepato- and renoprotective activities of CP. Conclusions: These results suggested that CP possesses beneficial potentials for use in treating hyperlipidemia and the underlying lipid-lowering mechanism might associate with a down-regulation of the intestinal-associated lipoprotein apoB48, which may provide evidence about its practical application for treating hyperlipidemia and its complications. (c) 2015 Elsevier Ireland Ltd. All rights reserved.
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