Journal
TISSUE ENGINEERING
Volume 11, Issue 1-2, Pages 302-309Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.2005.11.302
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL060435] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL-60435] Funding Source: Medline
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Vital organs maintain dense microvasculature to sustain the proper function of their cells. For tissue-engineered organs to function properly, artificial capillary networks must be developed. We have microfabricated capillary networks with a biodegradable and biocompatible elastomer, poly( glycerol sebacate) ( PGS). We etched capillary patterns onto silicon wafers by standard microelectromechanical systems (MEMS) techniques. The resultant silicon wafers served as micromolds for the devices. We bond the patterned PGS film with a flat film to create capillary networks that were perfused with a syringe pump at a physiological flow rate. The devices were endothelialized under flow conditions, and part of the lumens reached confluence within 14 days of culture. This approach may lead to tissue-engineered microvasculature that is critical in vital organs engineering.
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