Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 6, Issue 1, Pages 56-68Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1549
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A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
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