Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 7, Issue 1-2, Pages 108-118Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2005.7.108
Keywords
-
Funding
- NHLBI NIH HHS [HL67392, HL58774] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL067392, R01HL058774] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Cell division requires the coordinated assembly of cyclins and cyclin-dependent kinases that promote cell-cycle progression through S phase and mitosis. Two families of cyclin-dependent kinase inhibitors prevent abnormal or premature proliferation by blocking cyclin kinase activity. Expression of the cyclin-dependent kinase inhibitor p21, a member of the Cip/Kip family, increases when cells are damaged. In addition to controlling cell-cycle progression, p21 participates in DNA repair and apoptotic processes. The recent appreciation that p21 regulates cell survival and death implies that it is a master regulator of cell fate. This review discusses how p21 can affect the cellular response to oxidative stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available