Journal
KIDNEY & BLOOD PRESSURE RESEARCH
Volume 28, Issue 5-6, Pages 325-340Publisher
KARGER
DOI: 10.1159/000090187
Keywords
hypoxia-inducible factors; prolyl-hydroxylase inhibition; p53; acute renal failure; renal interstitial fibrosis
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Hypoxia-inducible factors (HIF) are ubiquitous transcription factors regulated by oxygen-dependent proteolysis, and hence rapidly mount an adaptational response to hypoxia. The HIF system is apparently more complex than initially considered in the perspective of the increasing number of HIF target genes, and the interrelationship with various additional regulatory pathways. Regional hypoxia is believed to play a major role in renal disease. Experimental data confirm a role for HIF in renal pathophysiology. The discovery of HIF prolyl-hydroxylases as key enzymes of oxygen sensing and HIF proteolysis offer new possibilities to therapeutically target HIF. Herein, we review basic concepts of HIF regulation, and existing data on HIF activation in renal disease. Copyright (c) 2005 S. Karger AG, Basel.
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