Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 6, Issue 1, Pages 69-78Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1551
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Transcription of rRNA and tRNA genes by RNA polymerases I and III is essential for sustained protein synthesis and is therefore a fundamental determinant of the capacity of a cell to grow. When cell growth is not required, this transcription is repressed by retinoblastoma protein, p53 and ARF. However, inactivation of these tumour suppressors in cancers deregulates RNA polymerases I and III, and oncoproteins such as Myc can stimulate these systems further. Such events might have a significant impact on the growth potential of tumours.
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