Journal
CURRENT MEDICINAL CHEMISTRY
Volume 12, Issue 6, Pages 657-666Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867053202214
Keywords
betulinic acid; anti-HIV derivatives; anti-HIV mechanism; anticancer derivatives; anticancer mechanism; antiinflammatory; antimalarial; biotransformation
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Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, anti inflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990's to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.
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