Journal
MOLECULAR PSYCHIATRY
Volume 10, Issue 1, Pages 117-126Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mp.4001618
Keywords
lithium; valproic acid; carbamazepine; inositol-depletion; inositol monophosphatase (IMPase); glycogen synthase kinase-3 (GSK-3)
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Inositol, a simple six-carbon sugar, forms the basis of a number of important intracellular signaling molecules. Over the last 35 years, a series of biochemical and cell biological experiments have shown that lithium (Li+) reduces the cellular concentration of myo-inositol and as a consequence attenuates signaling within the cell. Based on these observations, inositol-depletion was proposed as a therapeutic mechanism in the treatment of bipolar mood disorder. Recent results have added significant new dimensions to the original hypothesis. However, despite a number of clinical studies, this hypothesis still remains to be either proven or refuted. In this review of our current knowledge, I will consider where the inositol-depletion hypothesis stands today and how it may be further investigated in the future.
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