Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 35, Issue 1, Pages 1-9Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2004.09.004
Keywords
praziquantel; Ca2+ channels; schistosoma
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Funding
- NIAID NIH HHS [R01 AI040522, AI 40522] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI040522] Funding Source: NIH RePORTER
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Praziquantel is the current drug of choice for the control of schistosomiasis. It is highly effective against all species of schistosomes and shows minimal adverse effects. Though introduced for the treatment of schistosomiasis more than 20 years ago, the mode of action of praziquantel remains to be elucidated. This review will focus on advances in defining the molecular target of praziquantel action, with particular emphasis on recent work indicating an important role for voltage-gated calcium channels. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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