Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 126, Issue 1, Pages 17-21Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2004.09.013
Keywords
yeast aging; replicative life span; genome-wide; calorie restriction; Sir2
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Funding
- NATIONAL INSTITUTE ON AGING [P30AG013280] Funding Source: NIH RePORTER
- NIA NIH HHS [P30 AG013280] Funding Source: Medline
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Recent advances have suggested the existence of phylogenetically conserved pathways regulating ageing in eukaryotes. At least two of these public longevity-determining pathways appear to have been evolutionarily conserved from yeast through mammals. We have developed a high-throughput. genome-wide approach to identify a large fraction of the non-essential. single-gene deletion mutations that confer increased longevity in yeast. The identification and characterization of conserved genes that regulate the ageing process across eukaryotic species is likely to result in an improved understanding of the causes of human ageing and provide potential therapeutic targets for drug discovery. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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