Journal
CARDIOLOGY IN REVIEW
Volume 21, Issue 3, Pages 135-140Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CRD.0b013e318274956d
Keywords
energy metabolism; heart remodeling; beta-oxidation; glycolysis; mitochondrial dysfunction; cardiac failure
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Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal conditions. During heart remodeling, however, the fuel preference switches to glucose. In the earlier stages of cardiac remodeling, changes in energy metabolism are considered crucial to protect the heart from irreversible damage. Furthermore, low fatty acid oxidation and the stimulus for glycolytic pathway lead to lipotoxicity, acidosis, and low adenosine triphosphate production. While myocardial function is directly associated with energy metabolism, the metabolic pathways could be potential targets for therapy in heart failure.
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