Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 9, Issue 1, Pages 110-112Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op049838n
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The asymmetric hydrogenation of 1-aryl-2-imidazol-1-yl-ethanones offers a concise route to homochiral 1-aryl-2-imidazol-1-yl-ethanols. Catalytic asymmetric transfer hydrogenation with formic acid using [(R,R)-TsDPEN]Ru(Cymene)Cl as precatalyst was shown to be effective in this transformation. Preliminary process development showed that the hydrogenation could be carried out under mild conditions at a molar substrate-to-catalyst (SIC) ratio of 1000-2000.
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