Journal
GENOMICS
Volume 85, Issue 1, Pages 1-15Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2004.10.005
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM069090] Funding Source: NIH RePORTER
- NIGMS NIH HHS [F32 GM69090] Funding Source: Medline
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DNA microarrays are a well-established technology for measuring gene expression levels. Microarrays designed for this purpose use relatively few probes for each gene and are biased toward known and predicted gene structures. Recently, high-density oligonucleotide-based whole-genome microarrays have emerged as a preferred platform for genomic analysis beyond simple gene expression profiling. Potential uses for such whole-genome arrays include empirical annotation of the transcriptome, chromatin-immunoprecipitation-chip studies, analysis of alternative splicing, characterization of the methylome (the methylation state of the genome), polymorphism discovery and genotyping, comparative genome hybridization, and genome resequencing. Here we review different whole-genome microarray designs and applications of this technology to obtain a wide variety of genomic scale information. (C) 2004 Elsevier Inc. All rights reserved.
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