Journal
NEUROSCIENCE RESEARCH
Volume 51, Issue 1, Pages 111-115Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.neures.2004.09.012
Keywords
MPTP; olfactory bulb; neurodegeneration; dopamine; dopamine transporter
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The present study was undertaken to examine whether 1-methyI-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes damage of dopaminergic glomerular cells of the olfactory bulb (OB) in C57BL/6 mice. At 3 days after MPTP treatment, dopamine level in the striatum and the OB decreased to 13% and 84% of the control mice, respectively. While a small reduction of tyrosine hydroxylase protein level was observed in the OB of MPTP-treated mice, dopamine transporter (DAT) was undetectable at the protein level in this region. These results indicate that the DAT protein level could account for resistance of the OB to the Parkinsonism-inducing toxin. (C) 2004 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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