Journal
CEREBROVASCULAR DISEASES
Volume 19, Issue 3, Pages 192-200Publisher
KARGER
DOI: 10.1159/000083466
Keywords
Argatroban; brain edema; inflammatory cell; intracerebral hemorrhage; reactive astrocytes; thrombin
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This study investigated the effects of argatroban, a thrombin inhibitor, on brain edema and inflammation in a rat intracerebral hemorrhage (ICH) model. ICH was induced by injecting collagenase IV into the right caudate nucleus. Argatroban was administered intraperitoneally. Argatroban reduced brain edema from 44.6 to 14.3 mul at 72 h. Infiltration of polymorphonuclear leukocytes at 24 h and monocyte/macrophage at 24 and 72 h was significantly suppressed by argatroban. Argatroban did not increase the volume of hematoma. Systemic administration of argatroban reduced secondary brain damage including edema and inflammation in a rat ICH model. Copyright (C) 2005 S. Karger AG, Basel.
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