Journal
MOLECULES
Volume 10, Issue 1, Pages 146-161Publisher
MDPI
DOI: 10.3390/10010146
Keywords
microencapsulation technology; biodegradable polymer; drug delivery system
Funding
- NIBIB NIH HHS [EB003584, R21 EB003584] Funding Source: Medline
- NIGMS NIH HHS [R01 GM067044, GM 67044] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB003584] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067044] Funding Source: NIH RePORTER
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Drug delivery has become increasingly important mainly due to the awareness of the difficulties associated with a variety of old and new drugs. Of the many polymeric drug delivery systems, biodegradable polymers have been used widely as drug delivery systems because of their biocompatibility and biodegradability. The majority of biodegradable polymers have been used in the form of microparticles, from which the incorporated drug is released to the environment in a controlled manner. The factors responsible for controlling the drug release rate are physicochemical properties of drugs, degradation rate of polymers, and the morphology and size of microparticles. This review discusses the conventional and recent technologies for microencapsulation of the drugs using biodegradable polymers. In addition, this review presents characteristics and degradation behaviors of biodegradable polymers which are currently used in drug delivery.
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