Journal
FITOTERAPIA
Volume 76, Issue 1, Pages 50-53Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2004.10.008
Keywords
cytotoxic activity; justicidin B; Linum narbonense; Limun leonii
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Callus and suspension cultures of Linum narbonense and Linum leonii were developed to study the production of lignans and their cytotoxic activity. Justicidin B was determined to be the main lignan. The maximal yield of justicidin B up to 2.22 mg/g of the cell dry weight was detected in the callus cultures of L. leonii, followed by the callus cultures of L. narbonense (1.57 mg/g dwt). The cytotoxicity of the obtained extracts was measured using the MTT-dye assay. L. narbonense and L. leonii both showed cytotoxic activity. (C) 2004 Elsevier B.V. All rights reserved.
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