Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 126, Issue 1, Pages 209-215Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2004.09.021
Keywords
Foxo target genes; insulin pathway; comparative genomics; aging
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Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002600, R01HG001696] Funding Source: NIH RePORTER
- NHGRI NIH HHS [HG001696, HG002600] Funding Source: Medline
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Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead transcriptional regulators. Here we demonstrate how to identify, FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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