Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 112, Issue 1, Pages 121-125Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-004-0119-x
Keywords
astrocyte; synaptic transmission; glutamate
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS043142, R01NS037585, R37NS037585] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS37585, NS43142] Funding Source: Medline
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Astrocytes were long referred to as passive cells in the central nervous system (CNS). However, the application of fluorescent Ca2+ indicators revealed their Ca2+ excitability in response to a variety of stimuli. Since then, evidence showing that astrocytes release chemical transmitters and can modulate synapses has led to a new integrative view of the astrocyte. While it is inarguable that astrocytes play essential roles in nervous system function, and that gliotransmission modulates synapses, a significant challenge lies in developing the appropriate experimental strategy to allow unequivocal identification of roles for gliotransmission in nervous system function.
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