Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 30, Issue 9, Pages 515-521Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2005.07.001
Keywords
-
Categories
Ask authors/readers for more resources
Alternative mRNA splicing is becoming increasingly recognized as an important mechanism for the generation of structural and functional diversity in proteins. Recent estimations predict that similar to 50% of all eukaryotic proteins can be alternatively spliced. Several lines of evidence suggest that alternative mRNA splicing results in small changes in protein structure and is likely to fine-tune the function and specificity of the affected protein. However, knowledge of how alternative splicing regulates cellular processes on the molecular level is still limited. It is only recently that structures of alternatively spliced proteins have been solved. These studies have shown that alternative splicing affects the structure not only in the vicinity of the splice site but also at long distance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available