Journal
CARDIOLOGY
Volume 122, Issue 2, Pages 104-112Publisher
KARGER
DOI: 10.1159/000339271
Keywords
beta-Adrenergic receptors; G protein; beta-Blockers
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beta-Adrenergic receptors (beta-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical beta-blocker trials beta-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of beta-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways. Copyright (c) 2012 S. Karger AG, Basel
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