Journal
CARDIOLOGY
Volume 123, Issue 1, Pages 62-70Publisher
KARGER
DOI: 10.1159/000341277
Keywords
Blood pressure; Cardiovascular disease; Cardiovascular risk factors; Cholesterol; Hypercholesterolemia; Hypertension; Lipids; Metabolic syndrome; Prospective study; Vitamin D
Categories
Funding
- Danish Medical Research Council
- Danish Centre for Evaluation and Health Technology Assessment
- Novo Nordisk
- Copenhagen County
- Danish Heart Foundation
- Danish Pharmaceutical Association
- Health Insurance Foundation
- Augustinus Foundation
- Ib Henriksens foundation
- Beckett Foundation
- Health Insurance Foundation [2010 B 131]
- Danish Agency for Science Technology and Innovation [2101-06-0065]
- Novo Nordisk Foundation
- AP Moller Foundation
- Capital Region of Denmark
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Objectives: A low vitamin D level has been associated with increased cardiovascular disease risk but possible mechanisms remain unclear. We investigated the association between vitamin D levels and 5-year changes in blood pressure, lipid profile and incidence of the metabolic syndrome, hypertension and hypercholesterolemia. Methods: A random sample of 6,784 individuals aged 30-60 years from a general population was investigated in the Inter99 study in 1999-2001. Vitamin D (serum 25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography, and 4,330 individuals participated at the 5-year follow-up and were included in the present study. Results: The median baseline vitamin D concentration was 48.0 nmol/l. In nnultivariable linear regression analyses, a 10 nmol/l higher baseline level of vitamin D was associated with a decrease in triglycerides and very low density lipoprotein cholesterol by 0.52 (p = 0.03) and 0.66% (p = 0.005), respectively. In multivariable logistic regression analyses, the odds ratios per 10 nmol/l higher baseline vitamin D level were 0.95 (p < 0.05) and 0.94 (p = 0.01) for the development of the metabolic syndrome and hypercholesterolemia, respectively. There was no association between vitamin D and blood pressure. Conclusions: An optimal vitamin D status may influence cardiovascular health by changing the lipid profile in a favorable direction and decreasing the incidence of the metabolic syndrome. Copyright (C) 2012 S. Karger AG, Basel
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