Journal
JOURNAL OF ANTIBIOTICS
Volume 58, Issue 1, Pages 1-26Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2005.1
Keywords
bioactive microbial metabolites; biological origin; antibiotic and other bioactivities; chemical features; dereplication; the number of known compounds; future chances
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The short history, specific features and future prospects of research of microbial metabolites, including antibiotics and other bioactive metabolites, are summarized. The microbial origin, diversity of producing species, functions and various bioactivities of metabolites, unique features of their chemical structures are discussed, mainly on the basis of statistical data. The possible numbers of metabolites may be discovered in the future, the problems of dereplication of newly isolated compounds as well as the new trends and prospects of the research are also discussed.
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