Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 1, Pages 5-8Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2004.11.006
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Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR039555, R37AR039555] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR39555, AR32103] Funding Source: Medline
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In lymphopenic conditions, T cells expand to re-establish homeostasis by a process dependent on self-peptide-MHC recognition and the availability of proliferation- and survival-promoting cytokines. Although physiologically normal, chronic recurrence of this process might lead to selection of high-affinity self-reactive T-cell clones and autoimmune disease in susceptible individuals. A recent study in a diabetes-prone mouse model has provided strong evidence to support this hypothesis.
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