Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 31, Issue 6, Pages 527-534Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040500215750
Keywords
excipient; lipids; functionality; Gelucire (R) 44/14; self-emulsifying drug delivery system; melt granulation
Categories
Ask authors/readers for more resources
This paper focuses on the interest of a multifunctional lipid excipient from the lauroyl macrogolglycerides, i.e., Gelucire(R) 44/14. This compound, characterized by a drop point of 44 degrees C and a HLB ( Hydrophilic Lipophilic Balance) of 14, is made of a specific mixture, leading to particular properties. Gelucire(R) 44/14 forms a fine emulsion in contact with aqueous fluids, inducing a pseudo-solubilization of poorly water-soluble active substances and thus increasing their bioavailability. It could be used either as a binder for immediate release pellets by melt granulation or as a self-emulsifying drug delivery system by capsule molding or as a powder obtained by cryogenic grinding. These different methods and their interests are then discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available