Journal
CARDIOLOGY
Volume 116, Issue 4, Pages 271-278Publisher
KARGER
DOI: 10.1159/000316063
Keywords
Endothelial nitric oxide synthase gene; Coronary artery disease; Meta-analysis
Categories
Funding
- 863 program [2006AA02A407, 2009AA022701]
- 973 program [2010CB529600, 2006CB910601, 2007CB914703, 2007CB947300]
- Shanghai Municipal Commission of Science and Technology [09DJ1400601, 07DZ22917]
- Shanghai Municipal Health Bureau [2008095]
- Shanghai Changing Health Bureau [2008406002]
- National Key Project for Investigational New Drug [2008ZX09312-003]
- Shanghai Leading Academic Discipline Project [B205]
Ask authors/readers for more resources
Introduction: Previous case-control studies have suggested that the endothelial nitric oxide synthase (eNOS) gene polymorphisms (G894T, 4b/a, T-786C) are associated with coronary artery disease (CAD). However, other studies do not confirm these relationships. The objective was to assess these relationships using meta-analysis. Methods: Databases, including Pubmed and Embase, were searched to access the relevant genetic association studies up to July 2009. Results: The meta-analysis included 56 studies, consisting of 23 studies for G894T, 19 for 4b/a and 14 for T-786C. For the allelic analysis of the G894T variant, all studies showed a positively significant association (OR = 0.83, p = 0.004). For the genotypic analysis, the combined studies of the T allele showed significance (OR = 1.57, p = 0.003). For the allelic analysis of the T-786C variant, all studies showed an obviously significant association (OR = 0.79, p = 0.0007), reflected in both non-Asian and Asian studies. For the genotype analysis, combined studies of the C allele showed significance (OR = 0.72, p = 0.0001). Moreover, non-Asian studies showed significant results. For the analysis of the 4b/a variant, none of the studies showed significant results. No publication bias was found in the meta-analysis. Conclusion: The synthesis of available evidence supports the fact that eNOS G894T and T-786C are associated with CAD. Copyright (C) 2010 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available