Journal
CELL RESEARCH
Volume 15, Issue 1, Pages 49-51Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/sj.cr.7290264
Keywords
HGF/SF-Met; signaling; tumor progression
Categories
Ask authors/readers for more resources
Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in primary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available