Journal
TRENDS IN GENETICS
Volume 21, Issue 1, Pages 12-16Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2004.11.009
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Funding
- Telethon [TGM03S01, TGM06S01] Funding Source: Medline
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In metazoan organisms, energy production is the only example of a process that is under dual genetic control: nuclear and mitochondrial. We used a genomic approach to examine how energy genes of both the nuclear and mitochondrial genomes are coordinated, and discovered a novel genetic regulatory circuit in Drosophila melanogaster that is surprisingly simple and parsimonious. This circuit is based on a single DNA regulatory element and can explain both intra- and inter-genomic coordinated expression of genes involved in energy production, including the full complement of mitochondrial and nuclear oxidative phosphorylation genes, and the genes involved in the Krebs cycle.
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