Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 5, Issue 6, Pages 577-583Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026054367593
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This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biolopical activity are discussed.
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