Journal
TRENDS IN MOLECULAR MEDICINE
Volume 11, Issue 9, Pages 421-429Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2005.07.004
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Funding
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [Z01DE000230] Funding Source: NIH RePORTER
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Here, we review the biochemical and molecular properties of thymosin beta(4) (T beta(4)), the major actin-sequestering molecule in eukaryotic cells, and its key role in dermal-and corneal-wound healing. T beta(4) has several, novel, potential clinical applications in the repair and remodeling of ulcerated tissues and solid organs following hypoxic injuries, such as myocardial infarction and stroke. It might also have important repair functions in the pathophysiologic sequelae that are associated with actin toxicity and with septic shock, such as respiratory distress syndrome, multi-organ failure and severe tissue trauma.
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