Journal
CARCINOGENESIS
Volume 33, Issue 3, Pages 587-597Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgr307
Keywords
-
Categories
Funding
- National Institute of Health [1U19CA148127-01, HIN-CA77118, NIH-CA80127, R01CA060691, NIH R01CA87895, NIH N01-PC35145, NIH P30CA22453]
- German Research Foundation [GRK1034]
- Canadian Cancer Society [CCSRI 020214]
- Cancer Care Ontario Research Chair Award
- Mayo Clinic (MAYO): Mayo Foundation Fund
- Roy Castle Lung Cancer Foundation UK
- Memorial Sloan-Kettering Cancer Center (MSKCC)
- Labrecque Foundation
- Society of MSKCC
- World Cancer Research Fund
- European Commission [IC15-CT96-0313]
- Polish State Committee for Scientific Research [SPUB-M-COPERNICUS/P-05/DZ-30/99/2000]
- Wayne State University
- Karmanos Cancer Institute [WSU/KCI-1, WSU/KCI-2]
- University of California, San Francisco (UCSF): National Institutes of Environmental Health Sciences [ES06717]
- NCI [CA-113710]
- Danish Diet Cancer and Health Study (DDCHS)
- Danish Cancer Society
- Helmholtz lung cancer study: German Federal Ministry of Education, Science, Research and Technology, State of Bavaria, National Genome Research Network, German Research Foundation [BI 576/2-1, BI 576/2-2]
- Helmholtz Association
- Federal office for Radiation Protection [STSch4454]
Ask authors/readers for more resources
Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I-2 = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 95%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 95% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available