Journal
CARCINOGENESIS
Volume 31, Issue 12, Pages 2124-2126Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgq184
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Funding
- Italian Ministry of Health
- Associazione Italiana per la Ricerca sul Cancro - AIRC
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No allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients. Instead, our study suggests that mir-146a rs2910164 SNP may impact on the age of cancer onset. In fact, subjects with mir-146a a GC or CC genotypes developed tumors at younger age compared with individuals with the GG genotype Thus, in contrast to a recent report, our data support the hypothesis by Shen and coworkers of an association between the C allele of hsa-mir-146a and early cancer onset and prompt further investigations on the relevance of this polymorphism in early familial breast/ovarian tumor development.
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