Journal
NEUROTOXICOLOGY
Volume 26, Issue 1, Pages 133-140Publisher
ELSEVIER
DOI: 10.1016/j.neuro.2004.08.003
Keywords
particulate matter; inflammation; neurodegenerative diseases; air pollution
Categories
Funding
- NIA NIH HHS [AG16794] Funding Source: Medline
- NIEHS NIH HHS [ES7992] Funding Source: Medline
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES007992] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG016794] Funding Source: NIH RePORTER
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The etiology of neurodegenerative disorders is at present unknown. However, many of these disorders are associated with an increase in oxidative and inflammatory events. Although a small percentage of these disorders are familial cases linked to specific genetic defects, most are idiopathic. Thus, environmental factors are thought to play an important role in the onset and progression of such disorders. We have demonstrated that exposure (4 h, 5 days per week for 2 weeks) to concentrated airborne particulate matter increases inflammatory indices in brain of ovalbumin-sensitized BALB/c mice. Animals were divided into three exposure groups: filtered air (control), ultrafine particles, or fine and ultrafine particles. The levels of proinflammatory cytokines interleukin-1 alpha (IL-1alpha) and tumor necrosis factor alpha (TNF-alpha) were increased in brain tissue of mice exposed to particulate matter compared to that of control animals. Levels of the immunerelated transcription factor NF-kappaB were also found to be substantially elevated in the brain of exposed groups compared with the control group. These data indicate that components of inhaled particulate matter may trigger a proinflammatory response in nervous tissue that could contribute to the pathophysiology of neurodegenerative diseases. (C) 2004 Elsevier Inc. All rights reserved.
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