Journal
HIPPOCAMPUS
Volume 15, Issue 3, Pages 340-346Publisher
WILEY
DOI: 10.1002/hipo.20076
Keywords
rat; water maze; retrograde amnesia; hippocampus
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH024600] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P50AG005131] Funding Source: NIH RePORTER
- NIA NIH HHS [P50 AG05131, P50 AG005131] Funding Source: Medline
- NIMH NIH HHS [R01 MH024600-32, R01 MH024600] Funding Source: Medline
- PHS HHS [24600] Funding Source: Medline
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Damage to the hippocampus typically produces temporally graded retrograde amnesia, whereby memories acquired recently are impaired more than memories acquired remotely. This phenomenon has been demonstrated repeatedly in a variety of species and tasks, and it as figured prominently in theoretical treatments of memory and hippocampal pal function. A striking exception to the finding of tempora like retrograde amnesia comes from studies with rodents using spatial tasks. the water maze. In these studies, recent and remote memory were similarly impaired following hippocampal lesions. in contrast to work with rodents, studies of patients with medial temporal lobe lesions, including complete hippocampal lesions, indicate that remote spatial memory can in be intact. One difference between studies in rodents is that spatial memory in animal studies is acquired during a limited period of time when the animals are adults. In contrast, the spatial memory studied in humans was acquired beginning at an early age and learning continued for a considerable period of time. We initiated training d at in a standard water maze immediately after rats had been weaned 21 days of age and continued training until the rats were young adults (90 days old). Large hippocampal lesions were made 100 days after the completion of training. After recovery from surgery, control rats exhibited good retention on the first retention probe trial, but rats with hippocampal lesions performed at chance. Thus, even after extended training beginning early in life, and with prolonged training-surgery interval, hippocampal and with a life lesions impair performance in the water maze task. Possible reasons for these findings are discussed in the context of the specific performance requirements of the water maze task. Published 2005 Wiley-Liss, Inc.
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