Journal
CARCINOGENESIS
Volume 31, Issue 3, Pages 462-465Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgp315
Keywords
-
Categories
Funding
- Associazione and Fondazione Italiana Ricerca Cancro,
- Fondo Investimenti Ricerca di Base, Italy
- CEGEN (Spanish National Genotyping Centre)
- Centro Nacional de Investigaciones Oncologicas Node, Spain
Ask authors/readers for more resources
We analyzed a series of young (median age = 52 years) non-smoker lung cancer patients and their unaffected siblings as controls, using a genome-wide 620 901 single-nucleotide polymorphism (SNP) array analysis and a case-control DNA pooling approach. We identified 82 putatively associated SNPs that were retested by individual genotyping followed by use of the sib transmission disequilibrium test, pointing to 36 SNPs associated with lung cancer risk in the discordant sibs series. Analysis of these 36 SNPs in a polygenic model characterized by additive and interchangeable effects of rare alleles revealed a highly statistically significant dosage-dependent association between risk allele carrier status and proportion of cancer cases. Replication of the same 36 SNPs in a population-based series confirmed the association with lung cancer for three SNPs, suggesting that phenocopies and genetic heterogeneity can play a major role in the complex genetics of lung cancer risk in the general population.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available