Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 29, Issue 4-5, Pages 761-770Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2005.03.016
Keywords
anhedonia; hedonia; depression; lipopolysachharide; endotoxin; cytokines
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Funding
- NIDA NIH HHS [DA 15126-01] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R03DA015126] Funding Source: NIH RePORTER
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In humans, exposure to endotoxins or pro-inflammatory cytokines induces a number of neuropsychological symptoms collectively refer-red to as 'flu-like syndrome'. The degree of overlap between flu-like syndrome and major depressive disorder is considerable and a close linkage between these has been predicted to arise due to hypersecretion of endogenous pro-inflammatory cytokines and activation of the hypothalamic pituitary adrenal axis. In animals, exposure to pro-inflammatory cytokines or endotoxins induces a 'sickness behavior' syndrome that is analogous to flu-like symptoms observed in human patients. The goal of the current paper is to review evidence implicating endotoxin- or cytokine-induced sickness behavior as an animal model of depression, with an emphasis on reduced consumption of highly palatable substances as a defining feature. (c) 2005 Elsevier Ltd. All rights reserved.
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