Journal
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY
Volume 99, Issue 1, Pages 3-9Publisher
MANEY PUBLISHING
DOI: 10.1179/136485905X16372
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Although pentavalent antimonials are often used in the first- line treatment of cutaneous leishmaniasis ( CL), they have several adverse effects. Intralesional administration of antimonials and other antileishmanial drugs can be painful. In the present, double- blind, randomized study, to determine if topical treatment with paromomycin is effective in the treatment of CL, 35 cases of CL were treated, twice daily for 30 days, with a commercial skin- care lotion containing 10% urea ( the placebo) and another 30 were similarly treated with the same lotion to which paromomycin sulphate had been added ( to give a concentration of 15%). Each case was assessed clinically 7, 14, 21 and 30 days after treatment began, and parasitologically 30 and 60 days after the initiation of treatment. Five ( 17%) and five ( 17%) of the cases treated with paromomycin showed complete healing, with the apparent clearance of amastigotes from their lesions, 30 and 60 days after treatment began, respectively. At the same time- points, however, the lesions on six ( 17%) and seven ( 20%) of the cases in the placebo group, respectively, also appeared to have healed completely. Ointment containing 15% paromomycin therefore appears ineffective in the treatment of CL, at least when applied twice daily for 30 days to the lesions of cases from an endemic area of Isfahan, Iran.
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